Work

DNA and RNA polymerase/DNA complex imaged by scanning force microscopy: Influence of molecular‐scale friction

Year: 1992

Type: article

Abstract: Reproducible images of DNA and the interaction of RNA polymerase with supercoiled DNA on mica have been obtained by scanning force microscopy (SFM) in air. This technique allowed visualization of the assembly of distinct nucleoprotein complexes at specific sites which initiate DNA replication. Transmission electron microscopic controls were performed on the carbon‐coated replica of the same specimens previously scanned by scanning force microscope. Image contrast formation has been investigated and lateral friction forces have been qualitatively characterized with SFM on DNA‐covered samples.

Source: Scanning

DOI: 10.1002/sca.4950140405

Authors: F. Zenhausern, M. Adrian, B. Ten Heggeler‐Bordier, L. M. Eng, P. Descouts

Institutions: University of Geneva, University of Lausanne

Language: English

Topic: Force Microscopy Techniques and Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funder: H2020 European Research Council

OpenAlex ID: W2081883839

FWCI: 3.234

Cites: 23

Cited by: 53

Related to: 10