Population versus Customized Fetal Growth Norms and Adverse Outcomes in an Intrapartum Cohort
Year: 2012
Type: article
Abstract: OBJECTIVE: To compare population versus customized fetal growth norms in identifying neonates at risk for adverse outcomes (APO) associated with small for gestational age (SGA). STUDY DESIGN: Secondary analysis of an intrapartum fetal pulse oximetry trial in nulliparous women at term. Birth weight percentiles were calculated using ethnicity- and gender-specific population norms and customized norms (Gardosi). RESULTS: Of the studied neonates, 508 (9.9%) and 584 (11.3%) were SGA by population (SGApop) and customized (SGAcust) norms, respectively. SGApop infants were significantly associated with a composite adverse neonatal outcome, neonatal intensive care admission, low fetal oxygen saturation, and reduced risk of cesarean delivery; both SGApop and SGAcust infants were associated with a 5-minute Apgar score < 4. The ability of customized and population birth weight percentiles in predicting APO was poor (12 of 14 APOs had area under the curve of <0.6). CONCLUSION: In this intrapartum cohort, neither customized nor normalized population norms adequately identified neonates at risk of APO related to SGA.
Source: American Journal of Perinatology
Authors: Yinglei Lai, Steven Bloom, Catherine Spong, Michael Varner, Dwight Rouse, Susan Ramin, Steve Caritis, Alan Peaceman, Yoram Sorokin, Anthony Sciscione, Brian Mercer, John Thorp, Fergal Malone, Margaret Harper, Jay Iams, Maged Costantine, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Institutions: George Washington University, The University of Texas Southwestern Medical Center, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Utah, University of Alabama at Birmingham, The University of Texas Health Science Center at Houston, University of Pittsburgh, Northwestern University, Wayne State University, Drexel University, MetroHealth Medical Center, Case Western Reserve University, University of North Carolina at Chapel Hill, Columbia University, Wake Forest University Health Sciences, Wake Forest University, The Ohio State University, The University of Texas Medical Branch at Galveston
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1216570417, Maternal Fetal Medicine Network: Data Coordinating Cent*, G1882602020, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network, G2254024324, NICHD Maternal Fetal Medicine Units Network, G2594613454, NICHD Maternal-Fetal Medicine Units (MFMU) Network, G284963502, G2925552923, G29782494, G307553905, G3170774280, NICHD Maternal Fetal Medicine Units Network, G3218948901, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Cooperative Multicenter Maternal Fetal Medicine Units Networks, G3786447104, G3875946430, G4027080872, Co-Operative Multicenter Trials in Obstetrics & Maternal Fetal Medicine, G4259014447, Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research Net, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, Multicenter Network of Maternal Fetal Medicine Units, G4657398957, G4772972313, G5050941685, G50908112, Maternal Fetal Medicine Units Network, G5864221601, G5987270356, G6113204387, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), G6657596466, G673807916, Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site, Maternal Fetal Medicine Network, G7372122175, G7674919133, G7750490871, NICHD Materal Fetal Medicine Units Network, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, G8650048904, G8759751075, G8919699124, G9000034342, G9000075942, G9000086688, G9000090292, G9000121484, G9000139331, G9000158709, G9000207554, G9000212338, G9000241794, G9000265967, G9000317447, UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network - Northwestern Study Center, Maternal-Fetal Medicine Units (MFMU) Network, Case Western Reserve University Center of the NICHD MFMU Network, Columbia University Maternal-Fetal Medicine Units Network Clinical Center, NICHD maternal fetal medicine units network, UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies, Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1), G922324195
OpenAlex ID: W2082063270