Work

Effects on bone of vascular interruption: Turnover and morphology in isotope-prelabelled rats

Year: 1985

Type: article

Abstract: The effects of bone devascularization were evaluated histologically and metabolically in rats prelabelled with 45Ca, 3H-tetracycline and 3H-proline by quantifying cortical bone resorption and formation. The interruption of blood supply to bone without invading its integrity resulted in a marked increase in bone turnover (resorption and formation) during the first and second months. The stimulated increase in bone resorption and formation did not affect the resultant mass of collagen and calcium. Thus, the increase in bone resorption was compensated by an equivalent increase in bone formation.

Source: Acta Orthopaedica Scandinavica

DOI: 10.3109/17453678508992979

Authors: Leroy Klein, Beth Dollinger, Victor M. Goldberg, Jocelyn M. Zika, Arnold E. Powell, Kingsbury G. Heiple

Institutions: University Hospitals of Cleveland, Case Western Reserve University

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: National Institutes of Health, National Institute on Aging