Work

The response regulator SprE controls the stability of RpoS.

Year: 1996

Type: article

Abstract: In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.6.2488

Authors: L A Pratt, T J Silhavy

Institutions: Princeton University, University of California, San Francisco

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: REGULATION OF THE MAJOR OUTER MEMBRANE PORIN PROTEINS