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Erythropoietin Production in Cultures of Goat Renal Glomeruli

Year: 1972

Type: article

Abstract: Cultures initiated with isolated goat-kidney glomeruli produce erythropoietin over periods of 7 months. Production seems dependent upon a minimum interval of about 30 days between changes of medium. Experiments distinguishing between erythropoietin, renal activator, and serum substrate support the conclusion that the factor released to the medium of long-term glomerular cultures is erythropoietin itself. The system offers promising opportunities for studying regulation of erythropoietin production, and possibly could be developed as a source of significant quantities of the hormone.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.69.12.3547

Authors: H. Burlington, Eugene P. Cronkite, Ursula Reincke, Esmail D. Zanjani

Institutions: City University of New York, Icahn School of Medicine at Mount Sinai, Brookhaven National Laboratory

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2082569330

FWCI: 3.907

Cites: 14

Cited by: 62

Related to: 10