Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
Year: 1984
Type: article
Study design: Clinical Trial
Abstract: Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.
Source: BMJ
Authors: B K Sharma, I A Santana, E C Wood, R P Walt, M Pereira, P Noone, P L Smith, C L Walters, R E Pounder
Institutions: The Royal Free Hospital, Leatherhead Food Research
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2082589958