Work

Targeting cytokine networks in KRAS-driven tumorigenesis

Year: 2014

Type: article

Abstract: KRAS is one of the most commonly mutated oncogenes in human tumors, and is typically associated with aggressive disease. Despite intensive study and years of effort, KRAS has remained refractory to targeted inhibition. Given the challenge of inhibiting KRAS directly, current approaches to KRAS targeted therapy have involved the disruption of downstream signaling pathways. However, combinations of drugs that target RAF/MEK and PI3K/AKT signaling have failed to live up to expectations in the clinic. Here we summarize the evidence that the cytokine signaling circuitry of KRAS-driven tumors represents an equally tractable drug target. Indeed, the incorporation of novel therapeutics that disrupts these cytokine signaling networks may hold the key to overcoming this seemingly impenetrable treatment barrier.

Source: Expert Review of Anticancer Therapy

DOI: 10.1586/14737140.2014.928596

Authors: Hadrien G Golay, David A Barbie

Institutions: Dana-Farber Cancer Institute, École Polytechnique Fédérale de Lausanne, Broad Institute, Harvard University, Massachusetts Institute of Technology

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute