The relationship among restless legs syndrome (Willis–Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease
Year: 2013
Type: review
Abstract: The relationship among hypertension, cardiovascular disease (CVD), and stroke is well established [ 24 ]. Hypertension, including higher pulse pressure [systolic (SBP) minus diastolic blood pressure (DBP)], is a major risk factor for myocardial infarction (MI), stroke, heart failure, and renal failure [ 70 , 88 ]. Increases in SBP and DBP are predictive of long-term risks for chronic heart disease and CVD and result in a progressive and linear increase in the risk of death from heart disease and stroke [ 24 , 83 ]. Prehypertension is a more recent disease classification and increases the relative risk for CVD, including a 3.5-fold elevated risk for MI and a 1.7-fold increased risk for coronary artery disease (CAD) [ 100 ]. Prehypertension was defined in the 7th report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-7) as systolic pressures of 120–139 mmHg and diastolic pressures of 80–89 mmHg [ 24 ]. A recent meta-analysis of cross-sectional and longitudinal studies reported that prehypertension has an estimated overall prevalence of 36 % and is higher in men (40 %) than in women (33 %) [ 48 ]. The prevalence of prehypertension remains constant for subjects aged <50 years and declines with age, presumably as older subjects are diagnosed with hypertension [ 49 ].
Source: Journal of Neurology
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Funders: GlaxoSmithKline, Sanofi, UCB Pharma
OpenAlex ID: W2082644972