Work

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity

Year: 2013

Type: review

Abstract: Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling pathways are critical for the maintenance of homeostatic and developmental processes; however, deregulation and chronic activation of JAK-STAT3 results in numerous diseases. Among others, obesity is currently being intensively studied. In obesity, chronic JAK-STAT3 is activated by the CNS by increased circulating leptin levels leading to the development of leptin resistance, whereas in the peripheral organs chronic IL-6-induced JAK-STAT3 impairs insulin action. We report the consequences of chronic JAK-STAT3 induced signaling as present under obese conditions in the main metabolic organs.

Source: JAK-STAT

DOI: 10.4161/jkst.23878

Authors: Claudia M. Wunderlich, Nadine Hövelmeyer, F. Thomas Wunderlich

Institutions: Max Planck Society, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2082776945

FWCI: 1.004

Cites: 99

Cited by: 177

Related to: 10