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Convection-enhanced delivery to the central nervous system

Year: 2014
Type: review
Abstract: Convection-enhanced delivery (CED) is a bulk flow-driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging tracers that are co-infused during drug delivery now permit accurate, noninvasive real-time tracking of convective infusate flow in nervous system tissues. The potential advantages of CED in the CNS over other currently available drug delivery techniques, including systemic delivery, intrathecal and/or intraventricular distribution, and polymer implantation, have led to its application in research studies and clinical trials. The authors review the biophysical principles of convective flow and the technology, properties, and clinical applications of convective delivery in the CNS.
DOI: 10.3171/2014.10.jns14229
Institutions: The Ohio State University Wexner Medical Center, National Institute of Neurological Disorders and Stroke, The Ohio State University, University of Florida, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, University of Virginia
Language: English
Subfield: Neurology
Open Access status: bronze
OpenAlex ID: W2082870228
FWCI: 0.998
Cites: 124
Cited by: 231
Related to: 10