Work

Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism

Year: 2012

Type: article

Abstract: Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y. In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR.

Source: FEBS Open Bio

DOI: 10.1016/j.fob.2012.07.007

Authors: Mohammed Al Bratty, Venkateswara R. Chintapalli, Julian A.T. Dow, Tong Zhang, David G. Watson

Institutions: University of Strathclyde, University of Glasgow

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,210

Funder: Directorate for Biological Sciences