Work

The mammalian clock and chronopharmacology

Year: 2013

Type: article

Abstract: Increases in our understanding of the molecular control of circadian rhythms and subsequent signaling pathways has allowed for new therapeutic drug targets to be identified as well as for a better understanding of how to more efficaciously and safely utilize current drugs. Here, we review recent advances in targeting components of the molecular clock in mammals for the development of novel therapeutics as well as describe the impact of the circadian rhythm on drug efficacy and toxicity.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2013.02.015

Authors: Kristine Griffett, Thomas P. Burris

Institution: Scripps Research Institute

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,880