Work

Spontaneous Amplification of the Actinorhodin Gene Cluster in Streptomyces coelicolor Involving Native Insertion Sequence IS 466

Year: 2008

Type: article

Abstract: We observed a spontaneous amplification of the Streptomyces coelicolor chromosome, including genes encoding biosynthetic enzymes of the antibiotic actinorhodin. A new junction of two tandem segments has, inserted within it, a third copy of a transposable element existing in two places elsewhere in the chromosome, suggesting its involvement in the amplification mechanism.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00131-08

Authors: E. M. Widenbrant, Hsiu-Hui Tsai, Carton W. Chen, C. M. Kao

Institutions: Stanford University, National Yang Ming University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2083064217

FWCI: 0.234

Cites: 20

Cited by: 11

Related to: 10