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Perfusion-CT: A Non-Invasive Tool to Monitor Regional Brain Perfusion in Traumatic Brain Injury Patients and Therapies Impacting it

Year: 2010

Type: article

Abstract: There is a growing body of evidence suggesting imaging biomarkers to select patients with traumatic brain injury (TBI) for therapies, and to monitor the effects of these treatments.In this setting, advanced neuroimaging techniques such as perfusion-CT (PCT) can offer more clinically relevant pathophysiologic information than purely structural imaging such as conventional noncontrast CT.Patients with altered brain PCT results might be considered for more aggressive and early treatment to prevent intracranial hypertension, whereas patients with preserved brain perfusion might benefit from less invasive treatment.From a clinical trial perspective, better stratification of the patient population, and the use of advanced neuroimaging as a biomarker for response to intervention, could be expected to significantly reduce the number of patients required to assess a treatment effect and, therefore, expedite the clinical trial process.This article reviews the fundamental of perfusion-CT technique and its application to TBI.

Source: The Open Neurosurgery Journal

DOI: 10.2174/1876529701003010059

Authors: Max Wintermark, Jean-Francois Soustie

Institutions: University of Virginia, Technion – Israel Institute of Technology, Rambam Health Care Campus

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2083296118