Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen
Year: 2000
Type: article
Abstract: High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.
Source: Journal of Virology
Authors: Juan Carlos Lopez Bernaldo de Quiros, W. Lesley Shupert, Andrew C. McNeil, Juan C. Gea-Banacloche, Mark Flanigan, Ann Savage, Lisa Martino, Emma E. Weiskopf, Hiromi Imamichi, Yi-Ming Zhang, Joseph Adelsburger, Randy Stevens, Philip M. Murphy, Peter A. Zimmerman, Claire W. Hallahan, Richard T. Davey, Mark Connors
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2083310958