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Immune Profiling to Predict Treatment Response from Extracorporeal Photopheresis in Graft-Versus-Host Disease

Year: 2014
Type: article
Abstract: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients receiving stem cell transplant. Extracorporeal photopheresis has demonstrated efficacy in a proportion of GVHD patients that are steroid refractory. However, given the expense, the challenging logistics, and unpredictable GVHD response to ECP, a predictive immune biomarker to assist with the selection of patients to treat with ECP can make this treatment modality more efficacious and cost-effective. One of the challenges of using leukocyte as biomarkers is that any single leukocyte population does not adequately describe the immune system.
DOI: 10.1016/j.bbmt.2013.12.444
Authors: Stefan Cordes, Deepti Warad, Michael Gustafson, Adam Armstrong, Gregory Butler, Mrinal Patnaik, William Hogan, Mark R. Litzow, Jeffrey Winters, Dennis Gastineau, Allan Dietz, Yi Lin, Eapen K. Jacob
Institution: Mayo Clinic
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2083313575
FWCI:
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