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A flow-based synthesis of Imatinib: the API of Gleevec

Year: 2010

Type: article

Abstract: A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

Source: Chemical Communications

DOI: 10.1039/c001550d

Authors: Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley

Institution: University of Cambridge

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Fluid Flow and Transfer Processes

Field: Chemical Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2083415062

FWCI: 17.14

Cites: 37

Cited by: 193

Related to: 10