Work

Acute leukemia arising from a myelodysplastic syndrome after long-term administration of lproplatin

Year: 1992

Type: article

Abstract: BACKGROUND: Iproplatin (cis-dichloro-transdihydroxybis-isopropylamine platinum IV; CHIP) is a second generation cisplatin derivative that was developed to retain the antineoplastic effect of cisplatin with fewer toxic effects. Early clinical studies showed moderate activity in some neoplasms, with disappointing results in tumors of the lower gastrointestinal tract. Myelosuppression was the dose-limiting toxic effect in the acute setting. METHODS: The authors report a patient with metastatic adenocarcinoma of the colon who received long-term therapy with CHIP. RESULTS: The patient achieved complete remission of disease after prolonged treatment with CHIP. The patient subsequently had a myelodysplastic syndrome that rapidly transformed to acute myelogenous leukemia. CONCLUSIONS: Acute leukemia may represent a late complication of CHIP therapy.

Source: Cancer

DOI: 10.1002/1097-0142(19920915)70:6<1536::aid-cncr2820700615>3.0.co;2-w

Authors: Sheila M. Lemke, Stephen Graziano, Chaidong Cho, Bernard J. Poiesz

Institutions: SUNY Upstate Medical University, State University of New York, United States Department of Veterans Affairs, Veterans Health Administration, Syracuse VA Medical Center

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2083477800

FWCI: 0.249

Cites: 10

Cited by: 4

Related to: 10