Work

Enhancing integrin function by VEGF/neuropilin signaling

Year: 2012

Type: review

Abstract: This review advances the hypothesis that the ability of integrins to engage their extracellular matrix ligands and signal can be regulated in tumor cells by vascular endothelial growth factor (VEGF), a major angiogenic factor that also has direct effects on the function of tumor cells. More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression.

Source: Cell Adhesion & Migration

DOI: 10.4161/cam.22419

Authors: Hira Lal Goel, Arthur M. Mercurio

Institution: University of Massachusetts Chan Medical School

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,306