V.O2 Kinetics and Clinical Factors Among Patients With Peripheral Artery Disease
Year: 2013
Type: article
Study design: Observational Study
Abstract: In Brief PURPOSE: To investigate the association between oxygen uptake ( O2) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath O2 was obtained to assess O2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded. RESULTS: Using univariate analyses, higher values of tau ([τ], ie, slowed O2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age ≤66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to O2 kinetics. Using multiple regression procedures, the identified predictors of slowed O2 kinetics were female gender (4.76 [95% CI: 1.49-8.03] seconds; P = .0049), non-Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age ≤66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD patients, slowed O2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment. We investigated the association between oxygen uptake (O2) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease. Slowed O2 kinetics were associated with female gender, non-Caucasian race, hypertension, and age (<66 years). In peripheral artery disease, O2 kinetics may be a factor in impairment of walking.
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2083648326