Work

Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals.

Year: 1979

Type: article

Abstract: 10 mg of monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees C. C1, C4, and C3 depletion of 52, 68, and 46% were typical of classical pathway activation. C1 binding and activation occurred when urate crystals were incubated with isolated precursor C1, and required the intact macromolecule, C1qrs. Activation of isolated C1 by urate crystals was not diminished by F(ab')2 anti-Fc under conditions in which C1 activation by aggregated immunoglobulin (G) was blocked by the F(ab')2 antibody.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci109360

Authors: P C Giclas, M H Ginsberg, N R Cooper

Institutions: National Jewish Health, Scripps Clinic

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health