Work

Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c

Year: 2013

Type: article

Abstract: Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.

Source: Chemical Communications

DOI: 10.1039/c3cc47207h

Authors: Daiana A. Capdevila, Damián Álvarez-Paggi, María A. Castro, Verónica Tórtora, Verónica Demicheli, Darío A. Estrín, Rafael Radi, Daniel H. Murgida

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Universidad de la República de Uruguay

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, U.S. Department of Energy, Agencia Nacional de Investigación e Innovación, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de la República Uruguay, National Institutes of Health, Office of Science, Agencia Nacional de Promoción Científica y Tecnológica, Secretaría de Ciencia y Técnica, Universidad de Buenos Aires

Award: G7378882120

OpenAlex ID: W2083829770

FWCI: 0.471

Cites: 26

Cited by: 21

Related to: 10