Work

Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging

Year: 2007

Type: article

Abstract: Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.

Source: Optics Letters

DOI: 10.1364/ol.32.001560

Authors: A. E. Desjardins, B. J. Vakoc, A. Bilenca, G. J. Tearney, B. E. Bouma

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: G1545476000, Natural History of Vulnerable Coronary Plaques