Work

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

Year: 2014

Type: review

Abstract: In this review, we summarize the current knowledge about the membranous replication factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of these complex membrane rearrangements, because this topic emerged in the last few years as electron tomography has become more widely available. A general denominator is that two "morphotypes" of membrane alterations can be found that are exemplified by flaviviruses and hepaciviruses: membrane invaginations towards the lumen of the endoplasmatic reticulum (ER) and double membrane vesicles, representing extrusions also originating from the ER, respectively. We hypothesize that either morphotype might reflect common pathways and principles that are used by these viruses to form their membranous replication compartments.

Source: Viruses

DOI: 10.3390/v6072826

Authors: Inés Romero-Brey, Ralf Bartenschlager

Institution: Heidelberg University

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,137

Funders: Helsingin Yliopisto, European Molecular Biology Laboratory, Deutsche Forschungsgemeinschaft, Leids Universitair Medisch Centrum