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What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs

Year: 2014

Type: article

Abstract: The current manuscript describes the importance, mechanism propositions, evidence and controversies associated with multicomponent reactions (MCRs). The following multicomponent reactions are presented and critically evaluated: the Biginelli, Hantzsch, Mannich, Passerini and Ugi reactions. The aim of this review is to highlight what we already know about the mechanisms associated with these MCRs and the evidence supporting the proposed reaction pathways. Controversies and prospects are also discussed herein.

Source: RSC Advances

DOI: 10.1039/c4ra10651b

Authors: Haline G. O. Alvim, Eufrânio N. da Silva Júnior, Brenno A. D. Neto

Institutions: Universidade de Brasília, Universidade Federal de Minas Gerais

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Universidade de Brasília, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Financiadora de Estudos e Projetos, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Fundação de Apoio à Pesquisa do Distrito Federal, Universidade Católica de Brasília, Fundação de Empreendimentos Científicos e Tecnológicos

OpenAlex ID: W2083904809

FWCI: 8.286

Cites: 46

Cited by: 271

Related to: 10