Work

Regulatory T Cells: Historical Perspective

Year: 2007

Type: article

Abstract: The innate immune system, the earliest evolutionary form of defense against pathogens, provides a broad, relatively nonspecific form of immunity. In contrast, the adaptive immune system provides an efficient and specific line of defense against unique pathogens. Somatic cell rearrangements of their antigen-specific receptors provides essentially unlimited specificities, which are important given the high frequency of mutations found in infectious organisms. These specificities are predetermined and generated before encounters with antigens.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.10.009

Author: Nelson Chao

Institution: Duke Medical Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650