Year: 2013
Type: article
Abstract: Photoacoustic thermography is a promising tool for temperature measurement in deep tissue. Here we propose an absolute temperature measurement method based on the dual temperature dependences of the Grüneisen parameter and the speed of sound in tissue. By taking ratiometric measurements at two adjacent temperatures, we can eliminate the factors that are temperature irrelevant but difficult to correct for in deep tissue. To validate our method, absolute temperatures of blood-filled tubes embedded ~9 mm deep in chicken tissue were measured in a biologically relevant range from 28°C to 46°C. The temperature measurement accuracy was ~0.6°C. The results suggest that our method can be potentially used for absolute temperature monitoring in deep tissue during thermotherapy.
Source: Optics Letters
DOI: 10.1364/ol.38.005228
Institution: Washington University in St. Louis
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Photon tunneling: Shedding new light on biomedicine, G1952371934, RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING, Photoacoustic endoscopy of Barretts esophagus, Photoacoustic / Optical / Ultrasonic Imaging of Sentinel Lymph Nodes and Metastas, Monitoring of Breast Neoadjuvant Therapy by Thermo- and Photo- Acoustic Tomograph, PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPY, G9000084353, 21ST CENTURY IMAGING SCIENCES: GRADUATE STUDENT TRAINING
OpenAlex ID: W2084017774