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Gastrin-Releasing Peptide1–27, Unlike Bombesin, Does Not Reduce Sham Feeding in Rats

Year: 1997

Type: article

Abstract: Smith, J., S. Perez, P. A. Rushing, G. P. Smith and J. Gibbs. Gastrin-releasing peptide1–27, unlike bombesin, does not reduce sham feeding in rats. Peptides 18(9) 1465–1467, 1997.—We compared the potencies of systemic administration of bombesin (BN) and its mammalian homologue gastrin-releasing peptide (GRP) to decrease sham feeding in rats. Bombesin (at doses of 8, 16 and 32 μg/kg, intraperitoneally) inhibited sham feeding by 37% (p < 0.001), 58% (p < 0.001) and 65% (p < 0.001), respectively, confirming previous results. Gastrin-releasing peptide (16, 32, and 64 μg/kg) failed to affect sham feeding. Bombesin (16 μg/kg) and gastrin-releasing peptide (32 μg/kg) inhibited real feeding by 64% (p < 0.001) and 44% (p < 0.004), respectively. Pregastric food stimulation is not sufficient for the inhibitory action of GRP.

Source: Peptides

DOI: 10.1016/s0196-9781(97)00195-2

Authors: Jarilyn Smith, Sarah Perez, Paul A Rushing, Gerard P Smith, James Gibbs

Institution: Cornell University

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,710