Work

Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography

Year: 2010

Type: article

Abstract: We developed a straightforward, fast, and versatile technique to fabricate mineralized nanofibrous polymer scaffolds for bone regeneration in this work. Nanofibrous poly(l-lactic acid) scaffolds were fabricated using both electrospinning and phase separation techniques. An electrodeposition process was designed to deposit calcium phosphate on the nanofibrous scaffolds. Such scaffolds contain a high quality mineral coating on the fiber surface with tunable surface topography and chemical composition by varying the processing parameters, which can mimic the composition and structure of natural bone extracellular matrix and provide a more biocompatible interface for bone regeneration.

Source: Advanced Functional Materials

DOI: 10.1002/adfm.201000993

Authors: Chuanglong He, Guiyong Xiao, Xiaobing Jin, Chenghui Sun, Peter X. Ma

Institutions: Donghua University, University of Michigan, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: University of Michigan, China Scholarship Council, National Institute of Dental and Craniofacial Research

Awards: Orchestrating Bone Regeneration on Multiple Scales, Periodontal Engineering Using Biomimetic Nano Scaffolds