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Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

Year: 2012
Type: article
Abstract: To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4 ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.
Source: AIDS
DOI: 10.1097/qad.0b013e328351f627
Authors: David Croteau, Brookie M. Best, Scott Letendre, Steven S. Rossi, Ronald J. Ellis, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Justin C. Mcarthur, John Allen McCutchan, Susan Morgello, Igor Grant
Institutions: Rady Children's Hospital-San Diego, University of California San Diego, Washington University in St. Louis, University of Washington, The University of Texas Medical Branch at Galveston, Johns Hopkins University, Icahn School of Medicine at Mount Sinai
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2084246295
FWCI: 1.819
Cites: 12
Cited by: 18
Related to: 10