Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?
Year: 1995
Type: article
Abstract: C is a lymphocyte cell surface receptor originally discovered in a search for molecules having a role in T cell cytotoxicity (1). This molecule is a member of the immunoglobulin superfamily and is homologous to another T cell surface receptor, CD28. Both CD28 and CTLA-4 bind the same counter-receptors, members of the B7 family on APCs. While the role of CD28 during T cell responses to antigen has been well studied, much less is known about the role of CTLA-4. Recent studies on the function of this molecule have been controversial and have yielded seemingly conflicting results. In this issue, a new study (2) provides further evidence on the function of this molecule and lends support to growing evidence that CTLA-4 is a receptor having unique function during an immune response. What follows in this article is an account of the development of this story, an analysis of
Author: P S Linsley
Institution: Bristol-Myers Squibb (United States)
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2084544247