Year: 2012
Type: article
Abstract: BACKGROUND AND PURPOSE: The European Federation of the Neurological Societies (EFNS) guidelines on the use of neuroimaging in the diagnosis and management of dementia are designed to revise and expand previous EFNS recommendations for the diagnosis and management of patients with Alzheimer's disease (AD) and to provide an overview of the evidence for the use of neuroimaging techniques in non-AD dementias, as well as general recommendations that apply to all types of dementia in clinical practice. METHODS: The task force working group reviewed evidence from original research articles, meta-analyses and systematic reviews, published before April 2012. The evidence was classified, and consensus recommendations were given and graded according to the EFNS guidance regulations. RESULTS: Structural imaging, which should be performed at least once in the diagnostic work-up of patients with cognitive impairment, serves to exclude other potentially treatable diseases, to recognize vascular lesions and to identify specific findings to help distinguish different forms of neurodegenerative types of dementia. Although typical cases of dementia may not benefit from routine functional imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural imaging work-up and in particular clinical settings. Amyloid imaging is likely to find clinical utility in several fields, including the stratification of patients with mild cognitive impairment into those with and without underlying AD and the evaluation of atypical AD presentations. CONCLUSIONS: A number of recommendations and good practice points are made to improve the diagnosis of AD and other dementias.
Source: European Journal of Neurology
Institutions: Vita-Salute San Raffaele University, Amsterdam UMC Location Vrije Universiteit Amsterdam, Institut du Cerveau, Université Pierre-et-Marie-Curie, UCL Queen Square Institute of Neurology, University College London, Centro San Giovanni di Dio Fatebenefratelli, Mayo Clinic, Copenhagen University Hospital, Rigshospitalet, University of California, San Francisco, University of Cambridge, Azienda Ospedaliero-Universitaria Careggi, German Center for Neurodegenerative Diseases, University of Rostock, University of California, Los Angeles, Karolinska Institutet
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Sanofi, Biogen, Teva Pharmaceutical Industries, Fondazione Italiana Sclerosi Multipla, BioClinica, National Institute for Health and Care Research, University of Cambridge, Ministero della Salute, Eisai, H. Lundbeck A/S, Serono Symposia International Foundation, National Institutes of Health, Medical Research Council, National Institute on Aging
OpenAlex ID: W2084706106