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Cover Picture: Design, Synthesis and Bioevaluation of an EphA2 Receptor‐Based Targeted Delivery System (ChemMedChem 7/2014)

Year: 2014

Type: article

Abstract: The front cover picture shows that targeted delivery of Taxol (surface and stick representation) can be accomplished by conjugating the drug with a specific agent (green rod shape) targeting the membrane-anchored EphA2 receptor (orange). Binding of the drug conjugate causes receptor phosphorylation (indicated by a P) and internalization via endocytosis. The EphA2-bound drug conjugate is therefore actively internalized in the lysosomes where it gets cleaved delivering free Taxol. The EphA2 receptor is overexpressed in cancer cells and during angiogenesis. Therefore, drug conjugates targeting this receptor can selectively deliver chemotherapeutic agents to tumors and their vasculature. For more details, see the Full Paper by Maurizio Pellecchia et al. on p. 1403 ff.

Source: ChemMedChem

DOI: 10.1002/cmdc.201490024

Authors: Elisa Barile, Si Wang, Swadesh K. Das, Roberta Noberini, Russell Dahl, John L. Stebbins, Elena B. Pasquale, Paul B. Fisher, Maurizio Pellecchia

Institutions: Sanford Burnham Prebys Medical Discovery Institute, Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center, Rosalind Franklin University of Medicine and Science

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2084709452

FWCI:

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