Year: 2012
Type: review
Abstract: Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.
Source: Head & Neck
DOI: 10.1002/hed.23110
Authors: Michael L. Hinni, Alfio Ferlito, Margaret S. Brandwein‐Gensler, Robert P. Takes, Carl E. Silver, William H. Westra, Raja R. Seethala, Juan P. Rodrigo, June Corry, Carol R. Bradford, Jennifer L. Hunt, Primož Strojan, Kenneth O. Devaney, Douglas R. Gnepp, Dana M. Hartl, Luiz P. Kowalski, Alessandra Rinaldo, Leon Barnes
Institutions: Mayo Clinic, Mayo Clinic in Arizona, Mayo Clinic Hospital, University of Udine, University of Alabama at Birmingham, Radboud University Nijmegen, Radboud University Medical Center, Albert Einstein College of Medicine, Montefiore Medical Center, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital, University of Pittsburgh, Hospital Universitario Central de Asturias, Peter MacCallum Cancer Centre, University of Michigan, Michigan Medicine, University of Arkansas for Medical Sciences, Institute of Oncology Ljubljana, Henry Ford Allegiance Health, Brown University, Rhode Island Hospital, Université Sorbonne Nouvelle, Institut Gustave Roussy, Laboratoire de Phonétique et Phonologie, AC Camargo Hospital
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2084746469