Work

AB-400, a New Tetraene Macrolide Isolated from Streptomyces costae.

Year: 2000

Type: article

Abstract: In our screening program for new antifungal compounds produced by microorganisms, a new natural tetraene macrolide AB-400 has been isolated from culture broth of Streptomyces costae.In addition, this strain produces the knowntetraene antibiotic pimaricin.Both antibiotics were found to have very similar structure and were compared by physico-chemical, spectral and microbiological methods.The compound supressed the growth of fungi and the activity is compared with another polyene macrolide, amphotericin B, nystatin, candicidin and pimaricin.The

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.53.623

Authors: LIBRADA M. CAÑEDO, LUIS COSTA, LUIS M. CRIADO, JOSÉ L. FERNÁNDEZ PUENTES, MIGUEL A. MORENO, KENNETH L. RINEHART

Institutions: Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, University of Illinois Urbana-Champaign

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: University of Illinois at Urbana-Champaign