Work

Enantioselective Synthesis of (+)-Isolysergol via Ring-Closing Metathesis

Year: 2010

Type: article

Abstract: The first enantioselective synthesis of (+)-isolysergol was completed in 12 steps from commercially available materials by a novel approach that features a late stage microwave-mediated, diastereomeric ring-closing metathesis catalyzed by a chiral molybdenum catalyst to simultaneously form the D ring and set the stereocenter at C(8).

Source: Organic Letters

DOI: 10.1021/ol100819f

Authors: Jason A. Deck, Stephen F. Martin

Institution: The University of Texas at Austin

Language: English

Topic: Synthetic Organic Chemistry Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G3647830492, Synthesis of Nitrogen Containing Natural Products