Work

Donor CD4 Cells Induce Host Microenvironment Inflammation After Nonmyeloablative Hematopoietic Cell Transplantation Which Suppresses Hematopoiesis and Contributes to Graft Rejection

Year: 2011

Type: article

Abstract: The toxicity of allogeneic hematopoietic cell transplantation (HCT) is reduced by nonmyeloablative (NM) conditioning; however, persistent host cells can exacerbate graft rejection. To study the dynamics of hematopoietic reconstitution after NM radiation in a minor-mismatched strain combination with high levels of engraftment resistance, BALB.K mice were given purified hematopoietic stem cells (HSC: cKit+Thy1.1loSca1+Lin-) +/- T cells (TC) from AKR/J donors. Recipients of pure HSC or HSC+CD8 TC regularly achieved stable mixed chimerism.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2010.12.240

Authors: A.M.S. Mueller, M. Florek, H. Hadeiba, J.A. Shizuru

Institution: Stanford University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650