Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter
Year: 2015
Type: article
Abstract: The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (K(d) = 303 nM) is described. Contrast agents such as the one described herein could be used as molecular probes to directly study the binding of small molecules to receptors such as DAT via MRI, PET or SPECT.
Source: Organic & Biomolecular Chemistry
DOI: 10.1039/c4ob02165g
Authors: Gregory R. Naumiec, Grace Lincourt, Jeremy P. Clever, Michael A. McGregor, Abraham Kovoor, Brenton DeBoef
Institution: University of Rhode Island
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2085037556