Work

Structural length-scale sensitivities of reflectance measurements in continuous random media under the Born approximation

Year: 2012

Type: article

Abstract: Which range of structures contributes to light scattering in a continuous random media, such as biological tissue? In this Letter, we present a model to study the structural length-scale sensitivity of scattering in continuous random media under the Born approximation. The scattering coefficient μs, backscattering coefficient μb, anisotropy factor g, and reduced scattering coefficient μs* as well as the shape of the spatial reflectance profile are calculated under this model. For media with a biologically relevant Henyey-Greenstein phase function with g∼0.93 at wavelength λ=633 nm, we report that μs* is sensitive to structural length-scales from 46.9 nm to 2.07 μm (i.e., λ/13 to 3λ), μb is sensitive from 26.7 to 320 nm (i.e., λ/24 to λ/2), and the spatial reflectance profile is sensitive from 30.8 nm to 2.71 μm (i.e., λ/21 to 4λ).

Source: Optics Letters

DOI: 10.1364/ol.37.005220

Authors: Andrew J. Radosevich, Ji Yi, Jeremy D. Rogers, Vadim Backman

Institution: Northwestern University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: G6885688680, Novel Biophotonics Methodology for Colon Cancer Screening, G9000211584