Year: 2006
Type: article
Abstract: Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos.
Source: FEBS Letters
Authors: Rui Aoki, Nao Suzuki, Bibhash C. Paria, Kazuhiro Sugihara, Tomoya O. Akama, Gerhard Raab, Masaya Miyoshi, Daita Nadano, Michiko N. Fukuda
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2085068695