Work

Impact of Somatic Mutations in the D-Loop of Mitochondrial DNA on the Survival of Oral Squamous Cell Carcinoma Patients

Year: 2015

Type: article

Abstract: OBJECTIVES: The aim of this study was to investigate somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in oral squamous cell carcinoma patients. MATERIALS AND METHODS: Surgical specimen confirmed by pathological examination and corresponding non-cancerous tissues were collected from 120 oral squamous cell carcinoma patients. The sequence in the D-loop of mtDNA from non-cancerous tissues was compared with that from paired cancer samples and any sequence differences were recognized as somatic mutations. RESULTS: Somatic mutations in the D-loop of mtDNA were identified in 75 (62.5%) oral squamous cell carcinoma patients and most of them occurred in the poly-C tract. Although there were no significant differences in demographic and tumor-related features between participants with and without somatic mutation, the mutation group had a better survival rate (5 year disease-specific survival rate: 64.0% vs. 43.0%, P = 0.0266). CONCLUSION: Somatic mutation in D-loop of mtDNA was associated with a better survival in oral squamous cell carcinoma patients.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0124322

Authors: Jin-Ching Lin, Chen-Chi Wang, Rong-San Jiang, Wen-Yi Wang, Shih-An Liu

Institutions: Taichung Veterans General Hospital, National Yang Ming University, Hungkuang University

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382