Work

Signal transduction and actin filament organization

Year: 1996

Type: review

Abstract: Small GTP-binding proteins of the Rho family appear to integrate extracellular signals from diverse receptor types and initiate rearrangements of F-actin. Active members of the Rho family, Rho and Rac, are now joined by Cdc42 which induces filopodia. Downstream of the Rho family proteins, actin polymerization may be induced by an increase in the availability of actin filament barbed ends. Actin organization may be affected by exposure of actin-binding sites on proteins such as vinculin and ezrin.

Source: Current Opinion in Cell Biology

DOI: 10.1016/s0955-0674(96)80050-0

Author: Sally H Zigmond

Institution: University of Pennsylvania

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases