Work

Long-term synaptic depression in the mammalian brain

Year: 1994

Type: review

Abstract: A generally accepted hypothesis in neurobiology has been that at the cellular level, memories are stored, at least in part, as long-term alterations in the strength of synaptic tranmission. In recent years, considerable attention has been paid to persistent, use-dependent mechanisms that increase synaptic strength, which are collectively referred to as long-term potentiation (LTP). This review shall examine the opposite phenomenon, use-dependent decreases in synaptic strength, or long-term depression (LTD). LTD is a broad term that is used to describe synaptic depression according to several different learning rules and in a wide variety of brain structures.

Source: Neuron

DOI: 10.1016/0896-6273(94)90205-4

Author: David J. Linden

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $10,400

Funder: National Institute of Mental Health