Work

A Modification of the Method of Dale and Laidlaw for Standardization of Posterior Pituitary Extract

Year: 1948

Type: article

Abstract: The activity of a posterior pituitary extract is still generally determined by the method intro- duced by Dale and Laidlaw (1912).They used the uterus of a virgin guinea-pig, and the assay consisted in setting limits to the potency of the test solution in terms of the standard solution by the usual ABBA grouping of doses.The method suffered from three defects.1. Suitable guinea-pigs were relatively scarce. The assay often required many hours.3. The error of the method was about 20 per cent (Gaddum, 1938).

Source: British Journal of Pharmacology and Chemotherapy

DOI: 10.1111/j.1476-5381.1948.tb00396.x

Author: PAMELA HOLTON

Institution: University of Oxford

Language: English

Topic: Analytical Methods in Pharmaceuticals

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2085640965

FWCI: 1.71

Cites: 3

Cited by: 249

Related to: 10