Work

Acetal‐Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non‐Phagocytic Cells

Year: 2010

Type: article

Abstract: A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and non-phagocytic cells with minimal toxicity.

Source: Advanced Materials

DOI: 10.1002/adma.201000307

Authors: Joel A. Cohen, Tristan T. Beaudette, Jessica L. Cohen, Kyle E. Broaders, Eric M. Bachelder, Jean M. J. Fréchet

Institution: University of California, Berkeley

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering