Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch
Year: 2014
Type: article
Abstract: The metastatic spread of tumor epithelial cells accounts for over 90% of cancer-specific mortality; however, the molecular mechanisms that govern tumor spread and distant recolonization remain unclear. In this issue of JCI, Rokavec and colleagues shine light on this murky aspect of tumor biology by focusing through the lens of microenvironmental contributions, namely inflammation, as driving signals that set off a delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs. This study provides in vivo evidence and identifies molecular players behind the elusive switch that drives the epithelial-to-mesenchymal transition and the mesenchymal-to-epithelial transition.
DOI: 10.1172/jci75239
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Role of Fibroblasts, Myeloid Cells and Matrix in PDAC, G1469273482, G1619438925, G1727840030, G1777725819, G2329611598, Targeting Pericytes in Cancer, G56615411, G6008258537, Epigenetic Modifications in Renal Fibrogenesis, Role of Fibroblasts in Cancer, Assembly of Type IV Collagen in Health and Disease, Cancer Center Support Grant
OpenAlex ID: W2085854462