Work

Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis

Year: 2013

Type: article

Abstract: OvoA is an iron(II) dependent sulfoxide synthase which catalyzes the first step in ovothiol A biosynthesis. This enzyme sulphurizes the C5 position of the imidazole side chain of L-histidine. We report the substrate specificity profile of this catalyst and present data which indicate that OvoA catalysis follows an thiol-ene type mechanism.

Source: Chemical Communications

DOI: 10.1039/c3cc42594k

Authors: Gabriel T. M. Mashabela, Florian P. Seebeck

Institutions: University of Cape Town, University of Basel

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

OpenAlex ID: W2086024378

FWCI: 1.883

Cites: 18

Cited by: 44

Related to: 10