A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions
Year: 2011
Type: article
Abstract: Transition metal complexes catalyze many important reactions that are employed in medicine, materials science, and energy production. Although high-throughput methods for the discovery of catalysts that would mirror related approaches for the discovery of medicinally active compounds have been the focus of much attention, these methods have not been sufficiently general or accessible to typical synthetic laboratories to be adopted widely. We report a method to evaluate a broad range of catalysts for potential coupling reactions with the use of simple laboratory equipment. Specifically, we screen an array of catalysts and ligands with a diverse mixture of substrates and then use mass spectrometry to identify reaction products that, by design, exceed the mass of any single substrate. With this method, we discovered a copper-catalyzed alkyne hydroamination and two nickel-catalyzed hydroarylation reactions, each of which displays excellent functional-group tolerance.
Source: Science
Authors: Daniel W. Robbins, John F. Hartwig
Institution: University of Illinois Urbana-Champaign
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: Amination and Etherification of Aryl Halides and Olefins, G2225206983, G222768804, Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S, PALLADIUM CATALYZED FORMATION OF ARYLAMINE AND ARYLETHER, CHEMISTRY OF COMPLEXES WITH TRANSITION METAL HETEROATOM BONDS: NOVEL INSERTION CHEMISTRY AND X-H BOND ACTIVATION
OpenAlex ID: W2086112748