Work

A Magnetoplasmonic Imaging Agent for Copper(I) with Dual Response by MRI and Dark Field Microscopy

Year: 2013

Type: article

Abstract: We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T1- and T2-weighted images, concomitantly with a decrease of surface plasmon resonance intensity.

Source: ACS Nano

DOI: 10.1021/nn400928z

Authors: Evan A. Weitz, Cutler Lewandowski, Eric D. Smolensky, Małgorzata Marjańska, Valérie C. Pierre

Institution: University of Minnesota

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green