Work

New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus

Year: 1997

Type: article

Abstract: Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a sensitive biomarker of oxidative DNA damage and also of oxidative stress. We have investigated oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus (NIDDM) by urinary 8-OHdG assessments. We determined the total urinary excretion of 8-OHdG from 24 h urine samples of 81 NIDDM patients 9 years after the initial diagnosis and of 100 non-diabetic control subjects matched for age and gender. The total 24 h urinary excretion of 8-OHdG was markedly higher in NIDDM patients than in control subjects (68.2 +/- 39.4 microg vs. 49.6 +/- 37.7 microg, P = 0.001). High glycosylated hemoglobin was associated with a high level of urinary 8-OHdG. The increased excretion of urinary 8-OHdG is seen as indicating an increased systemic level of oxidative DNA damage in NIDDM patients.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(97)01273-8

Authors: Janne Leinonen, Terho Lehtimäki, Shinya Toyokuni, Kunihiko Okada, Tomoyuki Tanaka, Hiroshi Hiai, Hirotomo Ochi, Pekka Laippala, Vappu Rantalaiho, Ole Wirta, Amos Pasternack, Hannu Alho

Institutions: Tampere University, University of Tampere, Tampere University Hospital, Kyoto University

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2086501877

FWCI: 4.657

Cites: 24

Cited by: 265

Related to: 10